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Page 1
Did you mean lps and liver diseases (4,263 results)?
Celastrol induces ferroptosis in activated HSCs to ameliorate hepatic fibrosis via targeting peroxiredoxins and HO-1.
Luo P, Liu D, Zhang Q, Yang F, Wong YK, Xia F, Zhang J, Chen J, Tian Y, Yang C, Dai L, Shen HM, Wang J. Luo P, et al. Acta Pharm Sin B. 2022 May;12(5):2300-2314. doi: 10.1016/j.apsb.2021.12.007. Epub 2021 Dec 18. Acta Pharm Sin B. 2022. PMID: 35646542 Free PMC article.
Celastrol, a natural bioactive triterpenoid extracted from Tripterygium wilfordii, shows effective anti-fibrotic and anti-inflammatory activities in multiple hepatic diseases. However, the exact molecular mechanisms of action and the direct protein targets of celastrol in …
Celastrol, a natural bioactive triterpenoid extracted from Tripterygium wilfordii, shows effective anti-fibrotic and anti-inflammatory activ …
Multi-omics profiling reveals Chitinase-3-like protein 1 as a key mediator in the crosstalk between sarcopenia and liver cancer.
Lu D, Lin Z, Wang R, Chen Z, Zhuo J, Xu L, Pan L, Li H, Yang X, He C, Shen W, Yang M, Li H, Chen H, Tan W, Wei X, Zheng S, Xu X. Lu D, et al. Redox Biol. 2022 Dec;58:102538. doi: 10.1016/j.redox.2022.102538. Epub 2022 Nov 12. Redox Biol. 2022. PMID: 36417796 Free PMC article.
Targeted lipid profiling further proved that CHI3L1 was able to activate arachidonic acid metabolism, leading to lipid peroxide (LPO) accumulation. Meanwhile, LPO inhibition could compromise the remarkable pro-cancerous effects of CHI3L1. In conclusion, sarcopenia a …
Targeted lipid profiling further proved that CHI3L1 was able to activate arachidonic acid metabolism, leading to lipid peroxide (LPO) …
Betulin prevents high fat diet-induced non-alcoholic fatty liver disease by mitigating oxidative stress and upregulating Nrf2 and SIRT1 in rats.
Farage AE, Abdo W, Osman A, Abdel-Kareem MA, Hakami ZH, Alsulimani A, Bin-Ammar A, Alanazi AS, Alsuwayt B, Alanazi MM, Antar SA, Kamel EM, Mahmoud AM. Farage AE, et al. Life Sci. 2023 Jun 1;322:121688. doi: 10.1016/j.lfs.2023.121688. Epub 2023 Apr 6. Life Sci. 2023. PMID: 37030617
Rats received HFD and BE (15 and 30 mg/kg) for 12 weeks and blood and liver samples were collected for analyses. HFD caused hyperlipidemia, cholesterol and triglycerides accumulation in the liver, hepatocellular ballooning, fibrosis, insulin resistance (IR), lipid p …
Rats received HFD and BE (15 and 30 mg/kg) for 12 weeks and blood and liver samples were collected for analyses. HFD caused hyperlipi …
Mitoquinone protects against acetaminophen-induced liver injury in an FSP1-dependent and GPX4-independent manner.
He X, Liang SM, Wang HQ, Tao L, Sun FF, Wang Y, Zhang C, Huang YC, Xu DX, Chen X. He X, et al. Toxicol Appl Pharmacol. 2023 Apr 15;465:116452. doi: 10.1016/j.taap.2023.116452. Epub 2023 Mar 7. Toxicol Appl Pharmacol. 2023. PMID: 36894071
MtROS and oxidized lipids were elevated in APAP-exposed hepatocytes. We discovered that APAP-induced hepatocyte death and liver injury were ameliorated by attenuation of protein nitration and LPO in MitoQ-pretreated mice. ...These results suggest that MitoQ may alle …
MtROS and oxidized lipids were elevated in APAP-exposed hepatocytes. We discovered that APAP-induced hepatocyte death and liver injur …
Effect of mitoquinone on liver metabolism and steatosis in obese and diabetic rats.
Fink BD, Yu L, Coppey L, Obrosov A, Shevalye H, Kerns RJ, Yorek MA, Sivitz WI. Fink BD, et al. Pharmacol Res Perspect. 2021 Feb;9(1):e00701. doi: 10.1002/prp2.701. Pharmacol Res Perspect. 2021. PMID: 33547885 Free PMC article.
MitoQ did not alter respiration or membrane potential in isolated liver mitochondria. MitoQ reduced liver fat and liver hydroperoxide levels but did not improve liver function as marked by circulating levels of aspartate and alanine aminotransferase (A …
MitoQ did not alter respiration or membrane potential in isolated liver mitochondria. MitoQ reduced liver fat and liver …
Low Dose of BPA Induces Liver Injury through Oxidative Stress, Inflammation and Apoptosis in Long-Evans Lactating Rats and Its Perinatal Effect on Female PND6 Offspring.
Linillos-Pradillo B, Rancan L, Paredes SD, Schlumpf M, Lichtensteiger W, Vara E, Tresguerres JÁF. Linillos-Pradillo B, et al. Int J Mol Sci. 2023 Feb 26;24(5):4585. doi: 10.3390/ijms24054585. Int J Mol Sci. 2023. PMID: 36902016 Free PMC article.
/day and 3.42 mg/kg b.w./day) to pregnant rats could induce liver injury by generating oxidative stress, inflammation and apoptosis, and whether these effects may be observed in female postnatal day-6 (PND6) offspring. Antioxidant enzymes (CAT, SOD, GR, GPx and GST), gluta …
/day and 3.42 mg/kg b.w./day) to pregnant rats could induce liver injury by generating oxidative stress, inflammation and apoptosis, …
Ferroptosis participated in inhaled polystyrene nanoplastics-induced liver injury and fibrosis.
Ge Y, Yang S, Zhang T, Gong S, Wan X, Zhu Y, Fang Y, Hu C, Yang F, Yin L, Pu Y, Chen Z, Liang G. Ge Y, et al. Sci Total Environ. 2024 Mar 15;916:170342. doi: 10.1016/j.scitotenv.2024.170342. Epub 2024 Jan 24. Sci Total Environ. 2024. PMID: 38278228
Moreover, after 4 weeks and 12 weeks of exposure, Masson staining and upregulated expression of TGF-beta, alpha-SMA, and Col1a1 identified that inhaled PS-NPs exposure triggered the progression of liver fibrosis with the exposure time prolonged. From the mechanistic perspe …
Moreover, after 4 weeks and 12 weeks of exposure, Masson staining and upregulated expression of TGF-beta, alpha-SMA, and Col1a1 identified t …
Fe3+-binding transferrin nanovesicles encapsulating sorafenib induce ferroptosis in hepatocellular carcinoma.
Xiao Y, Xu Z, Cheng Y, Huang R, Xie Y, Tsai HI, Zha H, Xi L, Wang K, Cheng X, Gao Y, Zhang C, Cheng F, Chen H. Xiao Y, et al. Biomater Res. 2023 Jul 1;27(1):63. doi: 10.1186/s40824-023-00401-x. Biomater Res. 2023. PMID: 37391845 Free PMC article.
RESULTS: In vivo and in vitro experiments revealed that SOR@TF-Fe(3+) NVs predominantly accumulate in the liver, and specifically targeted HCC cells overexpressing TFRC. Various tests demonstrated SOR@TF-Fe(3+) NVs accelerated Fe(3+) absorption and transformation in HCC ce …
RESULTS: In vivo and in vitro experiments revealed that SOR@TF-Fe(3+) NVs predominantly accumulate in the liver, and specifically tar …
Antioxidant and hepatoprotective effects of intracellular mycelium polysaccharides from Pleurotus geesteranus against alcoholic liver diseases.
Song X, Shen Q, Liu M, Zhang C, Zhang L, Ren Z, Wang W, Dong Y, Wang X, Zhang J, Jia L. Song X, et al. Int J Biol Macromol. 2018 Jul 15;114:979-988. doi: 10.1016/j.ijbiomac.2018.04.001. Epub 2018 Apr 4. Int J Biol Macromol. 2018. PMID: 29625223
In the present study, we investigated the antioxidant and hepatoprotective effects of intracellular mycelium polysaccharides from Pleurotus geesteranus (IMPP) to address acute alcoholic liver diseases (ALD). Animal studies have demonstrated that the hepatic paramete …
In the present study, we investigated the antioxidant and hepatoprotective effects of intracellular mycelium polysaccharides from Pleurotus …
Artemisia alleviates AGE-induced liver complications via MAPK and RAGE signaling pathways modulation: a combinatorial study.
Moulahoum H, Ghorbanizamani F, Khiari Z, Toumi M, Benazzoug Y, Tok K, Timur S, Zihnioglu F. Moulahoum H, et al. Mol Cell Biochem. 2022 Oct;477(10):2345-2357. doi: 10.1007/s11010-022-04437-w. Epub 2022 May 11. Mol Cell Biochem. 2022. PMID: 35543857
The extract was tested for its antiglycation and aggregation properties. Next, THLE-2 liver cells were challenged with AGEs, and the mechanistic markers were measured [TNF-alpha, IL-6, nitric oxide, total antioxidant capacity, lipid peroxidation (LPO), and caspase 3 …
The extract was tested for its antiglycation and aggregation properties. Next, THLE-2 liver cells were challenged with AGEs, and the …
451 results